Originally Paul Manfred Glaser, he was born in Cambridge, Massachusetts, the youngest of three children. His parents were Dorothy and Samuel Glaser. Glaser attended Tulane University, where he was roommates with film director Bruce Paltrow and earned a Master's degree in English and theater in 1966. He was a member of the Sigma Alpha Mu fraternity. He earned a second master's degree from Boston University in acting and directing in 1967.
After appearing in several Broadway productions, Glaser appeared in his first feature film in 1971, playing Perchik in the film version of Fiddler on the Roof. He first gained notice on television playing Dr. Peter Chernak on the daytime series Love is a Many Splendored Thing, but found fame playing Detective David Starsky in the television show "Starsky and Hutch", for which he directed several episodes. After the show, Glaser continued to act on television and in films, and directed the 1992 movie The Cutting Edge as well as episodes of several well-known TV series, including "Judging Amy". Glaser returned to the big screen in 2004 in both Something's Gotta Give and with a brief cameo in Starsky & Hutch, where his old role was reprised by Ben Stiller.
Glaser has been married twice. He married his first wife, Elizabeth (Meyer) Glaser, in 1980. In 1981, Elizabeth contracted HIV through a blood transfusion while giving birth to the couple's first child, Ariel, but didn't find out about the virus until four years later, at which time both Ariel and son Jake were also found to be HIV positive. Ariel Glaser died in 1988; Elizabeth Glaser died in 1994, after founding the Elizabeth Glaser Pediatric AIDS Foundation. After Elizabeth's death, Glaser served as chairman of the foundation until 2002 and remains Honorary Chairman, roles in which he has testified before Congress and met with national leaders, as well as headlining annual fundraisers for the organization.
Glaser married producer Tracy Barone in 1996; the couple had a daughter, Zoe, in 1997.
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